You get your routine blood test done, open the report, and suddenly one number catches your attention:

Creatinine: High.

Your first thought might be, “Does this mean my kidneys are failing?”

Not necessarily.

Creatinine is an important marker used to assess kidney function, but one abnormal reading does not automatically mean you have kidney disease.
The result needs to be understood in the context of your overall health, other kidney tests and whether the level is changing over time.

• Creatinine is a waste product produced by normal muscle activity.
• Healthy kidneys filter creatinine from the blood and remove it through urine.
• When kidney function decreases, creatinine can build up in the bloodstream.
• Doctors use blood creatinine levels, along with other information, to estimate how well the kidneys are filtering.

• There is no single creatinine value that is considered normal for everyone.
• Reference ranges can vary between laboratories.
• Creatinine levels can also differ based on factors such as age, sex, muscle mass and certain medications.
• Your doctor may also look at your eGFR (estimated glomerular filtration rate), which provides a better picture of kidney function than creatinine alone.

• A raised creatinine level does not always mean permanent kidney damage.
  • Dehydration: Not drinking enough fluids can temporarily affect kidney function and raise creatinine.
  • Intense exercise: Strenuous physical activity can increase creatinine temporarily.
  • High muscle mass: People with greater muscle mass may naturally have higher creatinine levels.
  • Certain medicines: Some medications can affect creatinine levels or kidney function.
  • A high intake of cooked meat: Eating meat shortly before testing can temporarily influence creatinine levels.
  • Acute illness: Infections, low blood pressure or other conditions can temporarily affect kidney function.

  This is why one test result should not be interpreted in isolation.

• A creatinine level that remains elevated on repeat testing may require further evaluation.
• A significant or sudden increase can indicate acute kidney injury and should be assessed promptly.
• Persistently reduced eGFR can be a sign of chronic kidney disease.
• Conditions such as diabetes, high blood pressure and certain kidney disorders can increase the risk of kidney damage.

• Kidney disease can develop without obvious symptoms, particularly in its early stages.However, depending on the underlying problem, you may experience:
  • Swelling around the feet, ankles or face.
  • Changes in urination.
  • Blood or excessive foam in the urine.
  • Persistent fatigue.
  • Nausea or loss of appetite.
  • Breathlessness in more advanced cases.
  • Significant changes in urine output.

  Do not wait for symptoms to appear if you already have risk factors for kidney disease.

• Your doctor may:
  • Review your previous creatinine results to see whether the level is changing.
  • Check your eGFR and other blood or urine tests.
  • Review your medications and medical history.
  • Assess your hydration status and other possible causes.
  • Recommend additional investigations, such as a urine test or kidney ultrasound, when appropriate.
  • Refer you to a nephrologist if further kidney evaluation is needed.

• The goal is not simply to lower the creatinine number.
• The priority is to identify and treat whatever is causing the elevation.
• Staying adequately hydrated, managing diabetes and blood pressure, maintaining a healthy weight and avoiding unnecessary medicines or supplements that may affect the kidneys can support kidney health.
• Do not stop prescribed medication or make major dietary changes without speaking to your doctor.

A high creatinine number is a signal to investigate, not a reason to panic.

If your creatinine is elevated or you are concerned about your kidney function, consult the Nephrology Department at Horizon Prime Hospital for a comprehensive evaluation and personalised treatment plan.

Understand the number. Find the cause. Protect your kidneys.

Kidney transplant eligibility cannot be decided by age, blood group or one laboratory result alone. Recipients must be fit enough to benefit from transplantation, while living donors must be carefully protected from unacceptable short-term and long-term risks.

Considering a kidney transplant or living donation? Consult an experienced nephrologist and transplant team for a complete eligibility assessment, compatibility testing and clear guidance on the next steps.

Learn about the transplant team, hospital facilities and available support on the Kidney Transplant Care in Thane service page.

Name: Horizon Prime Hospital in Thane

Address: Vibgyor, Ghodbunder Rd, near Hiranandani Estate, behind Ritu Nissan Showroom, B Wing, Patlipada, Thane West, Thane, Maharashtra 400607

Phone: 022 6855 6855

Website: prime.horizonhospital.com